What is the reference of U19? I do not find any information about this chip in the documentation, and its marking is only “52A5”.
Looking at the schematic, it is clearly a chip controlling PWR_EN and PWR_LED according to the various standby and wake-up control signals. It could be a small microcontroller, or a dedicated chip similar to the SRC0, the STM660x, or the LTC2953. It would be interesting to have its datasheet to know exactly how it may react to its inputs, even though there does not seem to be anything fancy with it (simple on/off without button long push to force power off).